InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCP2

Summary

InnateDB Protein

IDBP-64058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCP2

Protein Name

uncoupling protein 2 (mitochondrial, proton carrier)

Synonyms

BMIQ4; SLC25A8; UCPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000312029

InnateDB Gene

IDBG-64056 (UCP2)

Protein Structure

UniProt Annotation

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006839	mitochondrial transport
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034198	cellular response to amino acid starvation
GO:0043066	negative regulation of apoptotic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051881	regulation of mitochondrial membrane potential
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542	response to fatty acid
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration