Version 5.4
Homo sapiens Protein: MBOAT1
Summary
InnateDB Protein IDBP-64118.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBOAT1
Protein Name membrane bound O-acyltransferase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000324944
InnateDB Gene IDBG-64116 (MBOAT1)
Protein Structure
UniProt Annotation
Function Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18772128}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in neutrophils. {ECO:0000269PubMed:18772128}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZNC8
PhosphoSite PhosphoSite-Q6ZNC8
TrEMBL
UniProt Splice Variant
Entrez Gene 154141
UniGene
RefSeq NP_001073949
HUGO HGNC:21579
OMIM 611732
CCDS CCDS34346
HPRD
IMGT
EMBL AB305043 AK093994 AK131269 AK296857 AK304748 AL008627 AL158198 AL355139 BC150650 BC150652
GenPept AAI50651 AAI50653 BAC04264 BAD18447 BAF93899 BAG59421 BAG65506 CAH71585 CAI19512 CAI20913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca