InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKAL1

Summary

InnateDB Protein

IDBP-64193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKAL1

Protein Name

CDK5 regulatory subunit associated protein 1-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000274695

InnateDB Gene

IDBG-64189 (CDKAL1)

Protein Structure

UniProt Annotation

Function

Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000269PubMed:20584901}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:23048041}; Single-pass membrane protein {ECO:0000269PubMed:23048041}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum.

Disease Associations

Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269PubMed:17460697, ECO:0000269PubMed:17463246}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in pancreatic islets. {ECO:0000269PubMed:23048041}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003824	catalytic activity
GO:0016740	transferase activity
GO:0035598	N6-threonylcarbomyladenosine methylthiotransferase activity
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0008150	biological_process
GO:0009451	RNA modification
GO:0035600	tRNA methylthiolation
GO:0043412	macromolecule modification
GO:1990145	maintenance of translational fidelity

Cellular Component

GO:0005575	cellular_component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002792 TRAM domain
IPR005839 Methylthiotransferase
IPR006466 MiaB-like tRNA modifying enzyme, archaeal-type
IPR006638 Elongator protein 3/MiaB/NifB
IPR007197 Radical SAM
IPR013848 Methylthiotransferase, N-terminal

PFAM

PF01938
PF04055
PF00919

PRINTS

PIRSF

SMART

SM00729

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VV42