InnateDB Protein
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IDBP-64285.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC9A4
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Protein Name
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solute carrier family 9 (sodium/hydrogen exchanger), member 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000295269
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InnateDB Gene
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IDBG-64283 (SLC9A4)
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Protein Structure
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Function |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Found in zymogen granule membranes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015299
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solute:proton antiporter activity
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GO:0015385
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sodium:proton antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001953
Na+/H+ exchanger, isoform 2 (NHE2)
IPR004709
Na+/H+ exchanger
IPR006153
Cation/H+ exchanger
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PFAM |
PF00999
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PRINTS |
PR01086
PR01084
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6AI14
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PhosphoSite |
PhosphoSite-Q6AI14
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
389015
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UniGene |
Hs.447686
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RefSeq |
NP_001011552
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HUGO |
HGNC:11077
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OMIM |
600531
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CCDS |
CCDS33264
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HPRD |
15973
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IMGT |
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EMBL |
AC007278
AL833048
CR627411
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GenPept |
CAH10500
CAH10600
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