InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9A2

Summary

InnateDB Protein

IDBP-64303.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A2

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 2

Synonyms

NHE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000233969

InnateDB Gene

IDBG-64301 (SLC9A2)

Protein Structure

UniProt Annotation

Function

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity

Biological Process

GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0008104	protein localization
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport