InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOX4

Summary

InnateDB Protein

IDBP-64342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOX4

Protein Name

SRY (sex determining region Y)-box 4

Synonyms

EVI16;

Species

Homo sapiens

Ensembl Protein

ENSP00000244745

InnateDB Gene

IDBG-64338 (SOX4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267, ECO:0000269PubMed:16631117}.

Disease Associations

Tissue Specificity

Testis, brain, and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046	core promoter sequence-specific DNA binding
GO:0001071	nucleic acid binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0001841	neural tube formation
GO:0002328	pro-B cell differentiation
GO:0003183	mitral valve morphogenesis
GO:0003211	cardiac ventricle formation
GO:0003215	cardiac right ventricle morphogenesis
GO:0003289	atrial septum primum morphogenesis
GO:0003357	noradrenergic neuron differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0014009	glial cell proliferation
GO:0021510	spinal cord development
GO:0021522	spinal cord motor neuron differentiation
GO:0021782	glial cell development
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030217	T cell differentiation
GO:0031018	endocrine pancreas development
GO:0031397	negative regulation of protein ubiquitination
GO:0031647	regulation of protein stability
GO:0032024	positive regulation of insulin secretion
GO:0035019	somatic stem cell maintenance
GO:0035910	ascending aorta morphogenesis
GO:0042593	glucose homeostasis
GO:0042769	DNA damage response, detection of DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0045727	positive regulation of translation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046826	negative regulation of protein export from nucleus
GO:0048485	sympathetic nervous system development
GO:0050821	protein stabilization
GO:0060070	canonical Wnt signaling pathway
GO:0060174	limb bud formation
GO:0060412	ventricular septum morphogenesis
GO:0060548	negative regulation of cell death
GO:0060563	neuroepithelial cell differentiation
GO:0060993	kidney morphogenesis
GO:0071333	cellular response to glucose stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000761	positive regulation of N-terminal peptidyl-lysine acetylation