InnateDB Protein
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IDBP-64399.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HINT2
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Protein Name
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histidine triad nucleotide binding protein 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000259667
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InnateDB Gene
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IDBG-64397 (HINT2)
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Protein Structure
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Function |
Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity. {ECO:0000269PubMed:16762638, ECO:0000269PubMed:18653718}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:16762638, ECO:0000269PubMed:18653718}.
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Disease Associations |
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Tissue Specificity |
High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients. {ECO:0000269PubMed:16762638}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001310
Histidine triad (HIT) protein
IPR011146
HIT-like domain
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PFAM |
PF01230
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PRINTS |
PR00332
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BX68
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PhosphoSite |
PhosphoSite-Q9BX68
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84681
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UniGene |
Hs.70573
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RefSeq |
NP_115982
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HUGO |
HGNC:18344
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OMIM |
609997
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CCDS |
CCDS6594
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HPRD |
17106
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IMGT |
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EMBL |
AF356515
AF356875
AF490476
AL133410
AY033094
BC047737
CH471071
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GenPept |
AAH47737
AAK37562
AAK53455
AAM00221
AAM09526
CAI10991
EAW58332
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