Version 5.4
Homo sapiens Protein: SLC15A4
Summary
InnateDB Protein IDBP-64445.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC15A4
Protein Name solute carrier family 15, member 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266771
InnateDB Gene IDBG-64443 (SLC15A4)
Protein Structure
UniProt Annotation
Function Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides. {ECO:0000269PubMed:16289537}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) and neural retina. Expressed in small intestine, stomach, duodenum, jejunum, ileum and colon. {ECO:0000269PubMed:11741232, ECO:0000269PubMed:11741260, ECO:0000269PubMed:16289537}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005290 L-histidine transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015817 histidine transport
GO:0045087 innate immune response (InnateDB)
GO:0055085 transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000109 Proton-dependent oligopeptide transporter family
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF00854
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N697
PhosphoSite PhosphoSite-Q8N697
TrEMBL F5GZQ7
UniProt Splice Variant
Entrez Gene 121260
UniGene Hs.741884
RefSeq NP_663623
HUGO HGNC:23090
OMIM 615806
CCDS CCDS9264
HPRD
IMGT
EMBL AC108704 AF461893 AK095717 AY038999 AY050629 BC028394 BC146803 CH471054
GenPept AAH28394 AAI46804 AAK72099 AAK95565 AAQ04807 BAG53113 EAW98494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca