InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF169

Summary

InnateDB Protein

IDBP-64481.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF169

Protein Name

ring finger protein 169

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299563

InnateDB Gene

IDBG-64479 (RNF169)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair. {ECO:0000269PubMed:22492721, ECO:0000269PubMed:22733822, ECO:0000269PubMed:22742833}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:22492721, ECO:0000269PubMed:22733822, ECO:0000269PubMed:22742833}. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031491	nucleosome binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005886	plasma membrane
GO:0035861	site of double-strand break
GO:0043231	intracellular membrane-bounded organelle