InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNCX

Summary

InnateDB Protein

IDBP-6455.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNCX

Protein Name

UNC homeobox

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000314480

InnateDB Gene

IDBG-6453 (UNCX)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001502	cartilage condensation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0010468	regulation of gene expression
GO:0021516	dorsal spinal cord development
GO:0021889	olfactory bulb interneuron differentiation
GO:0035726	common myeloid progenitor cell proliferation
GO:0045595	regulation of cell differentiation