InnateDB Protein
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IDBP-64757.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCDC2
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Protein Name
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doublecortin domain containing 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000367715
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InnateDB Gene
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IDBG-64753 (DCDC2)
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Protein Structure
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Function |
May be involved in neuronal migration during development of the cerebral neocortex. {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. {ECO:0000269PubMed:16278297}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus. {ECO:0000269PubMed:10601354, ECO:0000269PubMed:16278297}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003533
Doublecortin domain
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PFAM |
PF03607
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PRINTS |
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PIRSF |
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SMART |
SM00537
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UHG0
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PhosphoSite |
PhosphoSite-Q9UHG0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51473
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UniGene |
Hs.618980
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RefSeq |
NP_057440
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HUGO |
HGNC:18141
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OMIM |
605755
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CCDS |
CCDS4550
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HPRD |
09308
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IMGT |
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EMBL |
AB032980
AF181720
AF181721
AL133043
AL359389
AL359713
BC050704
FO393410
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GenPept |
AAF23610
AAF23612
AAH50704
BAA86468
CAB61371
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