Version 5.4
Homo sapiens Protein: ACPT
Summary
InnateDB Protein IDBP-64814.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACPT
Protein Name acid phosphatase, testicular
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000270593
InnateDB Gene IDBG-64812 (ACPT)
Protein Structure
UniProt Annotation
Function Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. {ECO:0000269PubMed:15219672}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow. {ECO:0000269PubMed:11414767}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003993 acid phosphatase activity
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily
PFAM PF00328
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZG2
PhosphoSite PhosphoSite-Q9BZG2
TrEMBL
UniProt Splice Variant
Entrez Gene 93650
UniGene Hs.293394
RefSeq NP_149059
HUGO HGNC:14376
OMIM 606362
CCDS CCDS12802
HPRD 06964
IMGT
EMBL AF321918
GenPept AAK09393 AAK09394 AAK09395 AAK09396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca