InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT1C4

Summary

InnateDB Protein

IDBP-64989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1C4

Protein Name

sulfotransferase family, cytosolic, 1C, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000272452

InnateDB Gene

IDBG-64987 (SULT1C4)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). {ECO:0000269PubMed:17425406}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation