Version 5.4
Homo sapiens Protein: UVRAG
Summary
InnateDB Protein IDBP-65038.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UVRAG
Protein Name UV radiation resistance associated gene
Synonyms DHTX; p63; VPS38;
Species Homo sapiens
Ensembl Protein ENSP00000348455
InnateDB Gene IDBG-65034 (UVRAG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Late endosome {ECO:0000269PubMed:18843052}. Lysosome {ECO:0000269PubMed:18843052}. Early endosome {ECO:0000269PubMed:18843052}. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.
Disease Associations Note=A chromosomal aberration involving UVRAG has been observed in a patient with heterotaxy (left-right axis malformation). Inversion Inv(11)(q13.5;q25).
Tissue Specificity Highly expressed in brain, lung, kidney and liver. {ECO:0000269PubMed:10798355}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0006281 DNA repair
GO:0010508 positive regulation of autophagy
GO:0035493 SNARE complex assembly
GO:0046718 viral entry into host cell
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2Y5
PhosphoSite PhosphoSite-Q9P2Y5
TrEMBL E9PR71
UniProt Splice Variant
Entrez Gene 7405
UniGene Hs.741452
RefSeq NP_003360
HUGO HGNC:12640
OMIM 602493
CCDS CCDS8241
HPRD 03929
IMGT
EMBL AB012958 AK095352 AK296871 AK316133 AP002340 AP003031 AP003168 X99050
GenPept BAA90829 BAG53033 BAG59434 BAH14504 CAA67507

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca