InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF3B

Summary

InnateDB Protein

IDBP-65049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF3B

Protein Name

kinesin family member 3B

Synonyms

FLA8; HH0048; KLP-11;

Species

Homo sapiens

Ensembl Protein

ENSP00000364864

InnateDB Gene

IDBG-65047 (KIF3B)

Protein Structure

UniProt Annotation

Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008574	plus-end-directed microtubule motor activity
GO:0017048	Rho GTPase binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007052	mitotic spindle organization
GO:0007100	mitotic centrosome separation
GO:0007368	determination of left/right symmetry
GO:0007596	blood coagulation
GO:0008089	anterograde axon cargo transport
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032467	positive regulation of cytokinesis
GO:0061024	membrane organization
GO:0072383	plus-end-directed vesicle transport along microtubule
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005873	plus-end kinesin complex
GO:0005876	spindle microtubule
GO:0005929	cilium
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0016939	kinesin II complex
GO:0030496	midbody
GO:0030990	intraciliary transport particle
GO:0070062	extracellular vesicular exosome