InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT11

Summary

InnateDB Protein

IDBP-65066.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT11

Protein Name

wingless-type MMTV integration site family, member 11

Synonyms

HWNT11;

Species

Homo sapiens

Ensembl Protein

ENSP00000325526

InnateDB Gene

IDBG-65064 (WNT11)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas. {ECO:0000269PubMed:11712081}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005099	Ras GTPase activator activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0030295	protein kinase activator activity
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001822	kidney development
GO:0003151	outflow tract morphogenesis
GO:0006468	protein phosphorylation
GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0030282	bone mineralization
GO:0030308	negative regulation of cell growth
GO:0030325	adrenal gland development
GO:0030335	positive regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0031667	response to nutrient levels
GO:0032320	positive regulation of Ras GTPase activity
GO:0032915	positive regulation of transforming growth factor beta2 production
GO:0034394	protein localization to cell surface
GO:0035567	non-canonical Wnt signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045165	cell fate commitment
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048706	embryonic skeletal system development
GO:0048844	artery morphogenesis
GO:0051496	positive regulation of stress fiber assembly
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060197	cloacal septation
GO:0060412	ventricular septum morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060548	negative regulation of cell death
GO:0060675	ureteric bud morphogenesis
GO:0061037	negative regulation of cartilage development
GO:0061101	neuroendocrine cell differentiation
GO:0070830	tight junction assembly
GO:0071300	cellular response to retinoic acid
GO:0072177	mesonephric duct development
GO:0072201	negative regulation of mesenchymal cell proliferation
GO:0090037	positive regulation of protein kinase C signaling
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090272	negative regulation of fibroblast growth factor production

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0031012	extracellular matrix