InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLK2

Summary

InnateDB Protein

IDBP-65082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLK2

Protein Name

kallikrein-related peptidase 2

Synonyms

hGK-1; hK2; KLK2A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000313581

InnateDB Gene

IDBG-65080 (KLK2)

Protein Structure

UniProt Annotation

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089

PRINTS

PR00722

PIRSF

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20151

PhosphoSite

PhosphoSite-P20151

TrEMBL

M0R2W5

UniProt Splice Variant

Entrez Gene

3817

UniGene

RefSeq

NP_005542

HUGO

HGNC:6363

OMIM

147960

CCDS

CCDS12808

HPRD

01006

IMGT

EMBL

AC011523 AC037199 AF188745 AF188746 AF188747 AF243527 AK300549 AK300566 AK315890 BC005196 BT006650 CH471135 M18156 M18157 S39329

GenPept

AAA74454 AAD13816 AAD13817 AAF08275 AAF08276 AAF08277 AAG33356 AAH05196 AAP35296 BAF98781 BAG62255 BAG62272 EAW71937 EAW71940