InnateDB Protein
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IDBP-65145.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EP400
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Protein Name
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E1A binding protein p400
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000333602
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InnateDB Gene
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IDBG-65143 (EP400)
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Protein Structure
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Function |
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:14966270, ECO:0000269PubMed:24463511}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00549}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:11509179}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013999
HAS subgroup
IPR014012
Helicase/SANT-associated, DNA binding
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PFAM |
PF07529
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PRINTS |
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PIRSF |
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SMART |
SM00573
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TIGRFAMs |
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Modification |
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SwissProt |
Q96L91
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PhosphoSite |
PhosphoSite-Q96L91
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57634
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UniGene |
Hs.724635
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RefSeq |
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HUGO |
HGNC:11958
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OMIM |
606265
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CCDS |
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HPRD |
09378
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IMGT |
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EMBL |
AB040931
AB058721
AC137590
AC137632
AK096311
AY044869
BC037208
BC064554
U80743
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GenPept |
AAB91441
AAH37208
AAH64554
AAK97789
BAA96022
BAB47447
BAC04759
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