Version 5.4
Homo sapiens Protein: EP400
Summary
InnateDB Protein IDBP-65147.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EP400
Protein Name E1A binding protein p400
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331737
InnateDB Gene IDBG-65143 (EP400)
Protein Structure
UniProt Annotation
Function Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:14966270, ECO:0000269PubMed:24463511}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00549}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11509179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006325 chromatin organization
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000812 Swr1 complex
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
GO:0035267 NuA4 histone acetyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR013999 HAS subgroup
IPR014012 Helicase/SANT-associated, DNA binding
PFAM PF07529
PRINTS
PIRSF
SMART SM00573
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96L91
PhosphoSite PhosphoSite-Q96L91
TrEMBL
UniProt Splice Variant
Entrez Gene 57634
UniGene Hs.724635
RefSeq
HUGO HGNC:11958
OMIM 606265
CCDS
HPRD 09378
IMGT
EMBL AB040931 AB058721 AC137590 AC137632 AK096311 AY044869 BC037208 BC064554 U80743
GenPept AAB91441 AAH37208 AAH64554 AAK97789 BAA96022 BAB47447 BAC04759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca