InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EP400

Summary

InnateDB Protein

IDBP-65153.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EP400

Protein Name

E1A binding protein p400

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374212

InnateDB Gene

IDBG-65143 (EP400)

Protein Structure

UniProt Annotation

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:14966270, ECO:0000269PubMed:24463511}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00549}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11509179}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005524	ATP binding

Biological Process

GO:0006325	chromatin organization
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000812	Swr1 complex
GO:0005654	nucleoplasm
GO:0016607	nuclear speck
GO:0035267	NuA4 histone acetyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR009057 Homeodomain-like
IPR013999 HAS subgroup
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014012 Helicase/SANT-associated, DNA binding
IPR017877 Myb-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF07529

PRINTS

PIRSF

SMART

SM00490
SM00573
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96L91