InnateDB Protein
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IDBP-65262.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MKX
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Protein Name
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mohawk homeobox
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000364946
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InnateDB Gene
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IDBG-65260 (MKX)
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Protein Structure
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Function |
May act as a morphogenetic regulator of cell adhesion. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0001085
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RNA polymerase II transcription factor binding
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GO:0003677
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DNA binding
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0002932
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tendon sheath development
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0007517
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muscle organ development
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GO:0010468
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regulation of gene expression
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GO:0010628
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positive regulation of gene expression
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GO:0030199
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collagen fibril organization
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GO:0032967
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positive regulation of collagen biosynthetic process
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GO:0035990
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tendon cell differentiation
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GO:0035992
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tendon formation
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GO:0045662
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negative regulation of myoblast differentiation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
|
Modification |
|
SwissProt |
Q8IYA7
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PhosphoSite |
PhosphoSite-Q8IYA7
|
TrEMBL |
H0YMU2
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UniProt Splice Variant |
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Entrez Gene |
283078
|
UniGene |
Hs.128193
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RefSeq |
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HUGO |
HGNC:23729
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OMIM |
601332
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CCDS |
CCDS7156
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HPRD |
12577
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IMGT |
|
EMBL |
AC024606
AK125339
BC036207
CH471072
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GenPept |
AAH36207
BAG54187
EAW86052
EAW86053
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