Version 5.4
Homo sapiens Protein: CACNG4
Summary
InnateDB Protein IDBP-65283.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNG4
Protein Name calcium channel, voltage-dependent, gamma subunit 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262138
InnateDB Gene IDBG-65281 (CACNG4)
Protein Structure
UniProt Annotation
Function Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269PubMed:21172611}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
Biological Process
GO:0006810 transport
GO:0007268 synaptic transmission
GO:0019226 transmission of nerve impulse
GO:0051899 membrane depolarization
GO:0070588 calcium ion transmembrane transport
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016021 integral component of membrane
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR005423 Voltage-dependent calcium channel, gamma-4 subunit
IPR006187 Claudin
IPR008368 Voltage-dependent calcium channel, gamma subunit
PFAM PF00822
PF13903
PRINTS PR01603
PR01077
PR01792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBN1
PhosphoSite PhosphoSite-Q9UBN1
TrEMBL A0A024R8J8
UniProt Splice Variant
Entrez Gene 27092
UniGene Hs.514423
RefSeq NP_055220
HUGO HGNC:1408
OMIM 606404
CCDS CCDS11667
HPRD 05911
IMGT
EMBL AF142622 AF142623 AF142624 AF142625 AF162692 AK315149 BC034532 CH471099
GenPept AAF03090 AAF14538 AAH34532 BAG37597 EAW89020 EAW89021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca