Version 5.4
Homo sapiens Protein: KLK11
Summary
InnateDB Protein IDBP-65478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK11
Protein Name kallikrein-related peptidase 11
Synonyms PRSS20; TLSP;
Species Homo sapiens
Ensembl Protein ENSP00000324414
InnateDB Gene IDBG-65474 (KLK11)
Protein Structure
UniProt Annotation
Function Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {ECO:0000269PubMed:10872828, ECO:0000269PubMed:16467084}.
Subcellular Localization Isoform 1: Secreted.Isoform 2: Golgi apparatus.
Disease Associations
Tissue Specificity Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). {ECO:0000269PubMed:10872828, ECO:0000269PubMed:16467084}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001254 Peptidase S1
IPR009003 Trypsin-like cysteine/serine peptidase domain
PFAM PF00089
PRINTS
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9UBX7
TrEMBL
UniProt Splice Variant
Entrez Gene 11012
UniGene Hs.57771
RefSeq
HUGO HGNC:6359
OMIM 604434
CCDS
HPRD 05114
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca