InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BPTF

Summary

InnateDB Protein

IDBP-65553.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPTF

Protein Name

bromodomain PHD finger transcription factor

Synonyms

FAC1; FALZ; NURF301;

Species

Homo sapiens

Ensembl Protein

ENSP00000307208

InnateDB Gene

IDBG-65551 (BPTF)

Protein Structure

UniProt Annotation

Function

Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

Subcellular Localization

Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid- containing plaques.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level). {ECO:0000269PubMed:10662542, ECO:0000269PubMed:10727212, ECO:0000269PubMed:7621746, ECO:0000269PubMed:9225734}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001892	embryonic placenta development
GO:0006200	ATP catabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007010	cytoskeleton organization
GO:0007420	brain development
GO:0007492	endoderm development
GO:0009952	anterior/posterior pattern specification
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0016589	NURF complex

Protein Structure and Domains

PDB ID

InterPro

IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR004022 DDT domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR013992 Adenylate cyclase-associated CAP, N-terminal
IPR018500 DDT domain, subgroup
IPR018501 DDT domain superfamily
IPR019787 Zinc finger, PHD-finger

PFAM

PF00439
PF02791
PF01213
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00297
SM00249
SM00571

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt