InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRHPR

Summary

InnateDB Protein

IDBP-65627.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRHPR

Protein Name

glyoxylate reductase/hydroxypyruvate reductase

Synonyms

GLXR; GLYD; PH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000313432

InnateDB Gene

IDBG-65625 (GRHPR)

Protein Structure

UniProt Annotation

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Subcellular Localization

Disease Associations

Hyperoxaluria primary 2 (HP2) [MIM:260000]: A disorder characterized by elevated urinary excretion of oxalate and L- glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease. {ECO:0000269PubMed:10484776}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Most abundantly expressed in the liver. {ECO:0000269PubMed:10679197}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008465	glycerate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016618	hydroxypyruvate reductase activity
GO:0030267	glyoxylate reductase (NADP) activity
GO:0031406	carboxylic acid binding
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding
GO:0051287	NAD binding
GO:0070402	NADPH binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0007588	excretion
GO:0008152	metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0043648	dicarboxylic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0051259	protein oligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03446
PF00389
PF02826
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UBQ7

PhosphoSite