InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLP2

Summary

InnateDB Protein

IDBP-65645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLP2

Protein Name

proteolipid protein 2 (colonic epithelium-enriched)

Synonyms

A4; A4LSB;

Species

Homo sapiens

Ensembl Protein

ENSP00000365500

InnateDB Gene

IDBG-65641 (PLP2)

Protein Structure

UniProt Annotation

Function

May play a role in cell differentiation in the intestinal epithelium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0019956	chemokine binding

Biological Process

GO:0006811	ion transport
GO:0006935	chemotaxis
GO:0019221	cytokine-mediated signaling pathway
GO:0034220	ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome