Homo sapiens Protein: SIGLEC9
Summary
InnateDB Protein IDBP-65666.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC9
Protein Name sialic acid binding Ig-like lectin 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000250360
InnateDB Gene IDBG-65664 (SIGLEC9)
Protein Structure
UniProt Annotation
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07686
PF00047
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y336
PhosphoSite PhosphoSite-Q9Y336
TrEMBL
UniProt Splice Variant
Entrez Gene 27180
UniGene Hs.245828
RefSeq NP_055256
HUGO HGNC:10878
OMIM 605640
CCDS CCDS12825
HPRD 16133
IMGT
EMBL AB026265 AC011473 AF135027 AF227924 AF247180 AK297043 AY358913 BC035365
GenPept AAD26428 AAF71455 AAF87223 AAG23261 AAH35365 AAQ89272 BAB41100 BAG59570