Version 5.4
Homo sapiens Protein: POLR1E
Summary
InnateDB Protein IDBP-65689.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR1E
Protein Name polymerase (RNA) I polypeptide E, 53kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367023
InnateDB Gene IDBG-65685 (POLR1E)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0009303 rRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
Protein Structure and Domains
PDB ID
InterPro IPR009668 RNA polymerase I associated factor, A49-like
PFAM PF06870
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZS1
PhosphoSite PhosphoSite-Q9GZS1
TrEMBL
UniProt Splice Variant
Entrez Gene 64425
UniGene
RefSeq XP_005251604
HUGO HGNC:17631
OMIM
CCDS
HPRD 15096
IMGT
EMBL AK023452 AK024032 AK091294 AL158156 BC001337 BC014331 CR457313
GenPept AAH01337 AAH14331 BAB14579 BAB14791 BAC03629 CAG33594 CAH73518 CAH73519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca