InnateDB Protein
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IDBP-65818.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ETFB
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Protein Name
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electron-transfer-flavoprotein, beta polypeptide
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Synonyms
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MADD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000311930
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InnateDB Gene
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IDBG-65816 (ETFB)
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Protein Structure
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Function |
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
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Subcellular Localization |
Mitochondrion matrix.
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Disease Associations |
Glutaric aciduria 2B (GA2B) [MIM:231680]: An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. {ECO:0000269PubMed:12815589, ECO:0000269PubMed:7912128}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0009055
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electron carrier activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012255
Electron transfer flavoprotein, beta subunit
IPR014730
Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
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PFAM |
PF01012
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PRINTS |
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PIRSF |
PIRSF000090
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SMART |
SM00893
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TIGRFAMs |
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Modification |
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SwissProt |
P38117
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PhosphoSite |
PhosphoSite-P38117
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
2109
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UniGene |
Hs.348531
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RefSeq |
NP_001976
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HUGO |
HGNC:3482
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OMIM |
130410
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CCDS |
CCDS12828
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HPRD |
00557
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IMGT |
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EMBL |
AF370381
AF436658
AF436659
AF436660
AF436661
AF436662
AF436663
AK055285
BC093961
BC093963
CR456827
X71129
X76067
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GenPept |
AAH93961
AAH93963
AAN03713
AAQ15217
BAG51494
CAA50441
CAB37832
CAG33108
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