InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THRSP

Summary

InnateDB Protein

IDBP-65844.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRSP

Protein Name

thyroid hormone responsive

Synonyms

Lpgp; LPGP1; S14; SPOT14; THRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000281030

InnateDB Gene

IDBG-65842 (THRSP)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. {ECO:0000250, ECO:0000269PubMed:17418816, ECO:0000269PubMed:18299245}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18299245}. Cytoplasm {ECO:0000269PubMed:18299245}.

Disease Associations

Tissue Specificity

Mainly expressed in tissues that synthesize triglycerides.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0010866	regulation of triglyceride biosynthetic process
GO:0046890	regulation of lipid biosynthetic process