InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAFK

Summary

InnateDB Protein

IDBP-6586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAFK

Protein Name

v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)

Synonyms

NFE2U; P18;

Species

Homo sapiens

Ensembl Protein

ENSP00000344903

InnateDB Gene

IDBG-6584 (MAFK)

Protein Structure

UniProt Annotation

Function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. {ECO:0000269PubMed:9150357}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001221	transcription cofactor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0007596	blood coagulation