InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAM82A2

Summary

InnateDB Protein

IDBP-6589.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAM82A2

Protein Name

family with sequence similarity 82, member A2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342493

InnateDB Gene

IDBG-6587 (FAM82A2)

Protein Structure

UniProt Annotation

Function

Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269PubMed:16820967, ECO:0000269PubMed:22131369}.

Subcellular Localization

Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Disease Associations

Tissue Specificity

Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. {ECO:0000269PubMed:15609043, ECO:0000269PubMed:16820967}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0006915	apoptotic process
GO:0030154	cell differentiation

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005874	microtubule
GO:0016021	integral component of membrane