Version 5.4
Homo sapiens Protein: PGAM5
Summary
InnateDB Protein IDBP-65906.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGAM5
Protein Name phosphoglycerate mutase family member 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000321503
InnateDB Gene IDBG-404450 (PGAM5)
Protein Structure
UniProt Annotation
Function Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. {ECO:0000269PubMed:18387606, ECO:0000269PubMed:19590015, ECO:0000269PubMed:22265414}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:18387606}; Single-pass membrane protein {ECO:0000269PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005096 GTPase activator activity
GO:0016791 phosphatase activity
GO:0032403 protein complex binding
Biological Process
GO:0016311 dephosphorylation
GO:0043547 positive regulation of GTPase activity
GO:0070266 necroptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013078 Histidine phosphatase superfamily, clade-1
IPR029033 Histidine phosphatase superfamily
PFAM PF00300
PRINTS
PIRSF
SMART SM00855
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HS1
PhosphoSite PhosphoSite-Q96HS1
TrEMBL
UniProt Splice Variant
Entrez Gene 192111
UniGene Hs.102558
RefSeq NP_612642
HUGO HGNC:28763
OMIM 614939
CCDS CCDS9280
HPRD 14681
IMGT
EMBL AC135586 AF357523 BC008196 EU249757
GenPept AAH08196 AAK60627 ABX39494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca