InnateDB Protein
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IDBP-6591.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FAM82A2
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Protein Name
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family with sequence similarity 82, member A2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000260385
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InnateDB Gene
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IDBG-6587 (FAM82A2)
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Protein Structure
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Function |
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269PubMed:16820967, ECO:0000269PubMed:22131369}.
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Subcellular Localization |
Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
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Disease Associations |
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Tissue Specificity |
Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. {ECO:0000269PubMed:15609043, ECO:0000269PubMed:16820967}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96TC7
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PhosphoSite |
PhosphoSite-Q96TC7
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TrEMBL |
H0YLG5
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UniProt Splice Variant |
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Entrez Gene |
55177
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UniGene |
Hs.632944
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RefSeq |
XP_005254588
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HUGO |
HGNC:25550
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OMIM |
611873
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CCDS |
CCDS10063
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HPRD |
07687
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IMGT |
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EMBL |
AB000782
AC012476
AJ242719
AK001441
AK025963
AK092058
AK123192
AK123282
AY358793
BC008970
BC063844
BR000691
CH471125
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GenPept |
AAH08970
AAH63844
AAQ89153
BAA91693
BAB15298
BAB46923
BAC85554
BAG52475
BAG53885
CAC39480
EAW92436
EAW92437
EAW92439
EAW92440
EAW92441
FAA00416
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