Version 5.4
Homo sapiens Protein: FAM65B
Summary
InnateDB Protein IDBP-65931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM65B
Protein Name family with sequence similarity 65, member B
Synonyms C6orf32; DIFF40; DIFF48; MYONAP; PL48;
Species Homo sapiens
Ensembl Protein ENSP00000259698
InnateDB Gene IDBG-65927 (FAM65B)
Protein Structure
UniProt Annotation
Function Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation. {ECO:0000269PubMed:17150207}.
Subcellular Localization Isoform 1: Mitochondrion.Isoform 2: Cytoplasm, cytoskeleton. Cell projection, filopodium. Note=Detected in cellular filopodia.
Disease Associations
Tissue Specificity Isoform 1 is present in the brain. Isoform 2 is expressed during differentiation of fetal primary myoblasts. Also shows marked expression during cytotrophoblast differentiation. {ECO:0000269PubMed:17150207, ECO:0000269PubMed:9055809}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007517 muscle organ development
GO:0030154 cell differentiation
Cellular Component
GO:0005739 mitochondrion
GO:0005856 cytoskeleton
GO:0030175 filopodium
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y4F9
PhosphoSite PhosphoSite-Q9Y4F9
TrEMBL H3BP45
UniProt Splice Variant
Entrez Gene 9750
UniGene Hs.559459
RefSeq NP_055537
HUGO HGNC:13872
OMIM 611410
CCDS CCDS47383
HPRD 12881
IMGT
EMBL AB002384 AL078584 AL133264 AL133268 AL160400 AL512428 BC001232 CH471087 U49187
GenPept AAC51134 AAH01232 BAA20840 CAH73086 CAH73087 CAI19934 CAI19935 EAW55470 EAW55471 EAW55472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca