InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BPIFB3

Summary

InnateDB Protein

IDBP-65954.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BPIFB3

Protein Name

BPI fold containing family B, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364643

InnateDB Gene

IDBG-65952 (BPIFB3)

Protein Structure

UniProt Annotation

Function

May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:12837268}. Note=According to PubMed:12837268, it is cytoplasmic.

Disease Associations

Tissue Specificity

Detected in nasal septal epithelium. {ECO:0000269PubMed:11971875}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008289	lipid binding

Biological Process

GO:0045087

innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001124 Lipid-binding serum glycoprotein, C-terminal
IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain

PFAM

PF02886
PF01273

PRINTS

PIRSF

SMART

SM00329
SM00328

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P59826