Version 5.4
Homo sapiens Protein: ZNF175
Summary
InnateDB Protein IDBP-66113.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF175
Protein Name zinc finger protein 175
Synonyms OTK18;
Species Homo sapiens
Ensembl Protein ENSP00000262259
InnateDB Gene IDBG-66111 (ZNF175)
Protein Structure
UniProt Annotation
Function Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity. {ECO:0000269PubMed:14688346}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051607 defense response to virus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y473
PhosphoSite PhosphoSite-Q9Y473
TrEMBL
UniProt Splice Variant
Entrez Gene 7728
UniGene Hs.119014
RefSeq NP_009078
HUGO HGNC:12964
OMIM 601139
CCDS CCDS12837
HPRD 03088
IMGT
EMBL AC018755 AK292687 BC052997 CH471135 D50419
GenPept AAF87843 AAH52997 BAA23362 BAF85376 EAW72030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca