Version 5.4
Homo sapiens Protein: ZC3H8
Summary
InnateDB Protein IDBP-66185.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZC3H8
Protein Name zinc finger CCCH-type containing 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000272570
InnateDB Gene IDBG-66183 (ZC3H8)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. {ECO:0000250, ECO:0000269PubMed:12077251, ECO:0000269PubMed:12153508, ECO:0000269PubMed:23932780}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23932780}. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0043029 T cell homeostasis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046677 response to antibiotic
GO:0070245 positive regulation of thymocyte apoptotic process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000571 Zinc finger, CCCH-type
PFAM PF00642
PRINTS
PIRSF
SMART SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N5P1
PhosphoSite PhosphoSite-Q8N5P1
TrEMBL Q53RD8
UniProt Splice Variant
Entrez Gene 84524
UniGene Hs.418416
RefSeq XP_005263883
HUGO HGNC:30941
OMIM
CCDS
HPRD 11695
IMGT
EMBL AC092645 AC115115 AF334161 BC032001
GenPept AAH32001 AAK13496 AAY14855 AAY24050

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca