InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIGLEC14

Summary

InnateDB Protein

IDBP-66191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIGLEC14

Protein Name

sialic acid binding Ig-like lectin 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354090

InnateDB Gene

IDBG-544190 (SIGLEC14)

Protein Structure

UniProt Annotation

Function

Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. {ECO:0000269PubMed:17012248}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17012248}; Single-pass type I membrane protein {ECO:0000269PubMed:17012248}.

Disease Associations

Tissue Specificity

Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Also detected in lung and testis. {ECO:0000269PubMed:17012248}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005529	sugar binding

Biological Process

GO:0007155	cell adhesion
GO:0045087	innate immune response

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08ET2