Version 5.4
Homo sapiens Protein: SCGN
Summary
InnateDB Protein IDBP-66197.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCGN
Protein Name secretagogin, EF-hand calcium binding protein
Synonyms CALBL; DJ501N12.8; SECRET; SEGN; setagin;
Species Homo sapiens
Ensembl Protein ENSP00000367197
InnateDB Gene IDBG-66195 (SCGN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm. Secreted {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions (By similarity). Detectable in human serum after ischemic neuronal damage. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. {ECO:0000269PubMed:11709487}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0030658 transport vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76038
PhosphoSite PhosphoSite-O76038
TrEMBL
UniProt Splice Variant
Entrez Gene 10590
UniGene Hs.116428
RefSeq NP_008929
HUGO HGNC:16941
OMIM 609202
CCDS CCDS4561
HPRD 10211
IMGT
EMBL AK289477 AL022170 AL512384 BC000336 BC003036 CH471087 Y16752
GenPept AAH00336 AAH03036 BAF82166 CAA76365 CAH72415 CAI21585 EAW55487

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca