InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAEA

Summary

InnateDB Protein

IDBP-6624.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAEA

Protein Name

macrophage erythroblast attacher

Synonyms

EMLP; EMP; GID9; HLC-10; PIG5;

Species

Homo sapiens

Ensembl Protein

ENSP00000302830

InnateDB Gene

IDBG-6622 (MAEA)

Protein Structure

UniProt Annotation

Function

Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. {ECO:0000269PubMed:16510120, ECO:0000269PubMed:9763581}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:16510120}. Cell membrane {ECO:0000269PubMed:16510120}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:16510120}. Note=Localized as nuclear speckled- like pattern.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:16510120, ECO:0000269PubMed:9763581}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007346	regulation of mitotic cell cycle
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0043249	erythrocyte maturation
GO:0048821	erythrocyte development
GO:0048822	enucleate erythrocyte development
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005819	spindle
GO:0005826	actomyosin contractile ring
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0015629	actin cytoskeleton
GO:0016363	nuclear matrix