InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBPL1

Summary

InnateDB Protein

IDBP-66289.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBPL1

Protein Name

insulin-like growth factor binding protein-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366923

InnateDB Gene

IDBG-66287 (IGFBPL1)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). May be a putative tumor suppressor protein. {ECO:0000250, ECO:0000269PubMed:15845387}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15845387}.

Disease Associations

Tissue Specificity

Expressed at the highest level in both brain and testis, with lower levels in the prostate, bladder and lung. {ECO:0000269PubMed:15845387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding

Biological Process

GO:0001558

regulation of cell growth

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR002350 Kazal domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain

PFAM

PF00219
PF00050
PF07648
PF07679
PF07686

PRINTS

PIRSF

PIRSF018239

SMART

SM00121
SM00280
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt