InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C14orf166

Summary

InnateDB Protein

IDBP-6631.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C14orf166

Protein Name

chromosome 14 open reading frame 166

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261700

InnateDB Gene

IDBG-6629 (C14orf166)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA- splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). {ECO:0000269PubMed:16950395, ECO:0000269PubMed:24608264, ECO:0000269PubMed:24870230}.

Subcellular Localization

Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269PubMed:24608264}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. {ECO:0000269PubMed:15147888}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0016032	viral process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0015629	actin cytoskeleton
GO:0048471	perinuclear region of cytoplasm
GO:0072669	tRNA-splicing ligase complex