Homo sapiens Protein: ZNF649
Summary
InnateDB Protein IDBP-66368.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF649
Protein Name zinc finger protein 649
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347043
InnateDB Gene IDBG-66366 (ZNF649)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways. {ECO:0000269PubMed:15950191}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15950191}.
Disease Associations
Tissue Specificity Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta. {ECO:0000269PubMed:15950191}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BS31
PhosphoSite PhosphoSite-Q9BS31
TrEMBL M0R098
UniProt Splice Variant
Entrez Gene 65251
UniGene Hs.148322
RefSeq NP_075562
HUGO HGNC:25741
OMIM 611903
CCDS CCDS12843
HPRD 07785
IMGT
EMBL AC011460 AK022706 AK315487 AL713677 BC005368 CH471135
GenPept AAH05368 BAB14191 BAG37871 CAD28482 EAW72050