InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NID2

Summary

InnateDB Protein

IDBP-6650.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NID2

Protein Name

nidogen 2 (osteonidogen)

Synonyms

NID-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000216286

InnateDB Gene

IDBG-6648 (NID2)

Protein Structure

UniProt Annotation

Function

Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0030198	extracellular matrix organization
GO:0071711	basement membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000716 Thyroglobulin type-1
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR003886 Nidogen, extracellular domain
IPR006605 G2 nidogen/fibulin G2F
IPR009017 Green fluorescent protein

PFAM

PF00058
PF00086
PF00008
PF07645
PF06119
PF07474

PRINTS

PIRSF

SMART

SM00135
SM00211
SM00181
SM00179
SM00539
SM00682

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14112