Version 5.4
Homo sapiens Protein: IL37
Summary
InnateDB Protein IDBP-66563.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL37
Protein Name interleukin 37
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263327
InnateDB Gene IDBG-66559 (IL37)
Protein Structure
UniProt Annotation
Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269PubMed:18390730, ECO:0000269PubMed:20935647}.
Subcellular Localization Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Disease Associations
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart. {ECO:0000269PubMed:11145836, ECO:0000269PubMed:20935647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01360
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZH6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27178
UniGene Hs.166371
RefSeq NP_775294
HUGO HGNC:15563
OMIM 605510
CCDS CCDS2104
HPRD 05695
IMGT
EMBL AB451333 AB451478 AC079753 AF167368 AF200496 AF201832 AF251118 AF251119 AF251120 AY071840 AY071841 AY973625 BC020637 CH471217
GenPept AAF25212 AAF69252 AAG14420 AAG14421 AAG14422 AAG29344 AAH20637 AAL67151 AAL67154 AAX59036 AAX88889 BAG70147 BAG70292 EAW73609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca