InnateDB Protein
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IDBP-66662.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL36G
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Protein Name
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interleukin 36, gamma
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365672
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InnateDB Gene
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IDBG-66658 (IL36G)
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Protein Structure
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Function |
Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highly expressed in tissues containing epithelial cells: skin, lung, stomach and esophagus. In skin is expressed only in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Up-regulated in lesional psoriasis skin.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005149
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interleukin-1 receptor binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000975
Interleukin-1 family
IPR003297
Interleukin-1 receptor antagonist / Interleukin-36
IPR008996
Cytokine, IL-1-like
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PFAM |
PF00340
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PRINTS |
PR00264
PR01360
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NZH8
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PhosphoSite |
PhosphoSite-Q9NZH8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56300
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UniGene |
Hs.211238
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RefSeq |
NP_001265497
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HUGO |
HGNC:15741
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OMIM |
605542
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CCDS |
CCDS62992
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HPRD |
05707
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IMGT |
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EMBL |
AC016724
AF200492
AF206696
AY359111
AY968311
BC096721
BC098130
BC098155
BC098337
BN000002
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GenPept |
AAF69248
AAG35670
AAH96721
AAH98130
AAH98155
AAH98337
AAQ89469
AAX59035
AAY14987
CAD29874
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