Version 5.4
Homo sapiens Protein: DCUN1D1
Summary
InnateDB Protein IDBP-66777.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCUN1D1
Protein Name DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000292782
InnateDB Gene IDBG-66775 (DCUN1D1)
Protein Structure
UniProt Annotation
Function Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas. {ECO:0000269PubMed:10777668}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 230 experimentally validated interaction(s) in this database.
Experimentally validated
Total 230 [view]
Protein-Protein 229 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0000151 ubiquitin ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR005176 Potentiating neddylation domain
IPR009060 UBA-like
PFAM PF03556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GG9
PhosphoSite PhosphoSite-Q96GG9
TrEMBL C9JVE2
UniProt Splice Variant
Entrez Gene 54165
UniGene Hs.743695
RefSeq NP_065691
HUGO HGNC:18184
OMIM 605905
CCDS CCDS3240
HPRD 12067
IMGT
EMBL AC092953 AF292100 AF456425 AF456426 AK025764 AK056335 AK314480 BC009478 BC013163 CH471052
GenPept AAG00606 AAH09478 AAH13163 AAL78672 AAL78673 BAB15235 BAG37084 BAG51680 EAW78341 EAW78342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca