Version 5.4
Homo sapiens Protein: LAMP3
Summary
InnateDB Protein IDBP-66858.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMP3
Protein Name lysosomal-associated membrane protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265598
InnateDB Gene IDBG-66856 (LAMP3)
Protein Structure
UniProt Annotation
Function May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269PubMed:9768752}.
Subcellular Localization Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.
Disease Associations
Tissue Specificity Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. {ECO:0000269PubMed:21930964, ECO:0000269PubMed:9721848, ECO:0000269PubMed:9768752}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002376 immune system process
GO:0008283 cell proliferation
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097233 alveolar lamellar body membrane
Protein Structure and Domains
PDB ID
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UQV4
PhosphoSite PhosphoSite-Q9UQV4
TrEMBL E7ETP9
UniProt Splice Variant
Entrez Gene 27074
UniGene Hs.619233
RefSeq NP_055213
HUGO HGNC:14582
OMIM 605883
CCDS CCDS3242
HPRD 12062
IMGT
EMBL AB013924 AC104641 AJ005766 BC032940 CH471052
GenPept AAH32940 BAA34533 CAA06691 EAW78337 EAW78338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca