InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C11orf73

Summary

InnateDB Protein

IDBP-66861.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C11orf73

Protein Name

chromosome 11 open reading frame 73

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000278483

InnateDB Gene

IDBG-66859 (C11orf73)

Protein Structure

UniProt Annotation

Function

Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. {ECO:0000269PubMed:22541429}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:22541429}. Nucleus {ECO:0000269PubMed:22541429}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008565	protein transporter activity
GO:0030544	Hsp70 protein binding

Biological Process

GO:0006606	protein import into nucleus
GO:0007030	Golgi organization
GO:0015031	protein transport
GO:0030324	lung development
GO:0034605	cellular response to heat